Article
Tumor necrosis factor-α -308 polymorphism in North Indian rheumatoid arthritis patients and association with mRNA and serum TNF-α.
Clinical rheumatology - 1 Oct 2017
Jahid Mohd, Rehan-Ul-Haq, Jha Puja Kumari, Chawla Diwesh, Avasthi Rajnish, Ahmed Rafat Sultana
Abstract excerpt
Rheumatoid arthritis (RA) is a severely disabling chronic autoimmune disorder that leads to progressive inflammation of the joints and surrounding tissues. TNF-α, a potent proinflammatory cytokine, plays a pivotal role in the pathogenesis of RA. The endogenous formation of TNF-α may be influenced by TNF-α promoter polymorphisms. Hence, the present study was designed to explore any possible association between...
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