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Article

Association analysis of two candidate polymorphisms in the tumour necrosis factor-α gene with osteoarthritis in a Chinese population.

International orthopaedics - 1 Oct 2013

Ji Bin, Shi Jixiang, Cheng Xiangyu, Zhou Junjie, Zhou Qiang, Cao Chengfu, Pang Jinhui

Abstract excerpt

PURPOSE: The purpose of this study was to investigate the possible association between single nucleotide polymorphisms (SNPs) rs1800629 (TNF-α -308) and rs361525 (TNF-α -238) of the tumour necrosis factor (TNF)-α gene and susceptibility to osteoarthritis (OA) in the Han Chinese population. METHODS: The TNF-α -308 and -238 genotypes were determined by TaqMan assay in 200 OA cases and 305 controls. Odds ratios...

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Identifiers

PMID: 23748461
DOI: 10.1007/s00264-013-1931-4
PMCID: PMC3779584

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TNF

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