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Article

LOXL1-AS1 contributes to metastasis in sonic-hedgehog medulloblastoma by promoting cancer stem-like phenotypes.

Journal of experimental & clinical cancer research : CR - 30 Apr 2024

Do Anh Duy, Wu Kuo-Sheng, Chu Shing-Shung, Giang Le Hien, Lin Yu-Ling, Chang Che-Chang, Wong Tai-Tong, Hsieh Chia-Ling, Sung Shian-Ying

Abstract excerpt

BACKGROUND: Medulloblastomas (MBs) are one of the most common malignant brain tumor types in children. MB prognosis, despite improvement in recent years, still depends on clinical and biological risk factors. Metastasis is the leading cause of MB-related deaths, which highlights an unmet need for risk stratification and targeted therapy to improve clinical outcomes. Among the four molecular subgroups,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38689348
DOI: 10.1186/s13046-024-03057-0
PMCID: PMC11059759

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