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Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

25 Apr 2022

Abstract excerpt

There is ample support for developmental regulation of glioblastoma stem cells. To examine how cell lineage controls glioblastoma stem cell function, we present a cross-species epigenome analysis of mouse and human glioblastoma stem cells. We analyze and compare the chromatin-accessibility landscape of nine mouse glioblastoma stem cell cultures of three defined origins and 60 patient-derived glioblastoma stem...

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Share to Epigenetics and DNA Methylation
Share to Glioma Diagnosis and Treatment
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PMID: 35469026
DOI: 10.1038/s41467-022-29912-2

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