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Article

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

1 Apr 2010

Abstract excerpt

Glioma growth and progression depend on a specialized subpopulation of tumour cells, termed tumour stem cells. Thus, tumour stem cells represent a critical therapeutic target, but the molecular mechanisms that regulate them are poorly understood. Hypoxia plays a key role in tumour progression and in this study we provide evidence that the hypoxic tumour microenvironment also controls tumour stem cells. We define...

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PMID: 20375133
DOI: 10.1093/brain/awq042

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