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Article

Generation of albino Xenopus tropicalis using zinc-finger nucleases.

Development, growth & differentiation - 1 Dec 2012

Nakajima Keisuke, Nakajima Taeko, Takase Minoru, Yaoita Yoshio

Abstract excerpt

To generate albino lines of Xenopus tropicalis, we injected fertilized eggs with mRNAs encoding zinc-finger nucleases (ZFNs) targeting the tyrosinase coding region. Surprisingly, vitiligo was observed on the skin of F0 frogs that had been injected with ZFN mRNAs, indicating that both tyrosinase genes in the genome were disrupted in all melanocytes within the vitiligo patches. Mutation analysis using genomic DNA...

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Identifiers

PMID: 23106502
DOI: 10.1111/dgd.12006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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