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Article

Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis.

Development (Cambridge, England) - 1 Feb 2014

Guo Xiaogang, Zhang Tiejun, Hu Zheng, Zhang Yanqi, Shi Zhaoying, Wang Qinhu, Cui Yan, Wang Fengqin, Zhao Hui, Chen Yonglong

Abstract excerpt

For the emerging amphibian genetic model Xenopus tropicalis targeted gene disruption is dependent on zinc-finger nucleases (ZFNs) or transcription activator-like effector nucleases (TALENs), which require either complex design and selection or laborious construction. Thus, easy and efficient genome editing tools are still highly desirable for this species. Here, we report that RNA-guided Cas9 nuclease resulted in...

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PMID: 24401372
DOI: 10.1242/dev.099853

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