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Article

Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system.

Genesis (New York, N.Y. : 2000) - 1 Dec 2013

Blitz Ira L, Biesinger Jacob, Xie Xiaohui, Cho Ken W Y

Abstract excerpt

Gene inactivation is an important tool for correlation of phenotypic and genomic data, allowing researchers to infer normal gene function based on the phenotype when the gene is impaired. New and better approaches are needed to overcome the shortfalls of existing methods for any significant acceleration of scientific progress. We have adapted the CRISPR/Cas system for use in Xenopus tropicalis and report on the...

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Identifiers

PMID: 24123579
DOI: 10.1002/dvg.22719
PMCID: PMC4039559

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Source receipt: pubmed, retrieved 7 Sept 2026.

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