Article
The tyrosinase gene of the i(b) albino mutant of the medaka fish carries a transposable element insertion in the promoter region.
Pigment cell research - 1 Apr 2004
Iida Atsuo, Inagaki Hidehito, Suzuki Miho, Wakamatsu Yuko, Hori Hiroshi, Koga Akihiko
Abstract excerpt
The i locus of the medaka fish contains the tyrosinase gene whose product is the key enzyme required for melanin biosynthesis. The i(b) allele at this locus, also denoted as i( 5), causes oculocutaneous albinism in homozygous carriers. Its albino phenotype is very weak, characterized mainly by small and varying sized melanophores in juveniles. Cloning and sequencing analyses of the tyrosinase gene for the i (b)...
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