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Article

Differential trafficking of TLR1 I602S underlies host protection against pathogenic mycobacteria.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2012

Hart Bryan E, Tapping Richard I

Abstract excerpt

We recently identified I602S as a frequent single-nucleotide polymorphism of human TLR1 that greatly inhibits cell surface trafficking, confers hyporesponsiveness to TLR1 agonists, and protects against the mycobacterial diseases leprosy and tuberculosis. Because mycobacteria are known to manipulate the TLR system to their advantage, we hypothesize that the hyporesponsive 602S variant may confer protection by...

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Identifiers

PMID: 23105135
DOI: 10.4049/jimmunol.1201545
PMCID: PMC3504178

Genes

TLR1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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