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Article

Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression.

Journal of leukocyte biology - 1 Aug 2011

Uciechowski Peter, Imhoff Heidi, Lange Christoph, Meyer Christian G, Browne Edmund N, Kirsten Detlef K, Schröder Anja K, Schaaf Bernhard, Al-Lahham Adnan, Reinert Ralf René, Reiling Norbert, Haase Hajo, Hatzmann Adelheid, Fleischer Daniela, Heussen Nicole, Kleines Michael, Rink Lothar

Abstract excerpt

Human TLR1 plays an important role in host defense against Mycobacterium tuberculosis. Our aim was to analyze the association of the loss of TLR1 surface expression and TLR1 SNPs with susceptibility to TB. TLR1neg and TLR1pos cells from healthy individuals were identified by flow cytometry and compared by sequencing. TLR1 expression was measured using quantitative real-time PCR and immunoblotting. TLR1 SNP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21642391
DOI: 10.1189/jlb.0409233

Genes

TLR1

Variants

Provenance

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