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Article

Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.

PLoS neglected tropical diseases - 7 May 2008

Misch Elizabeth A, Macdonald Murdo, Ranjit Chaman, Sapkota Bishwa R, Wells Richard D, Siddiqui M Ruby, Kaplan Gilla, Hawn Thomas R

Abstract excerpt

Toll-like receptors (TLRs) are important regulators of the innate immune response to pathogens, including Mycobacterium leprae, which is recognized by TLR1/2 heterodimers. We previously identified a transmembrane domain polymorphism, TLR1_T1805G, that encodes an isoleucine to serine substitution and is associated with impaired signaling. We hypothesized that this TLR1 SNP regulates the innate immune response and...

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Source

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Identifiers

PMID: 18461142
DOI: 10.1371/journal.pntd.0000231
PMCID: PMC2330092

Genes

TLR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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