Article
Toll-like receptor 1 N248S single-nucleotide polymorphism is associated with leprosy risk and regulates immune activation during mycobacterial infection.
The Journal of infectious diseases - 1 Jul 2013
Marques Carolinne de Sales, Brito-de-Souza Vânia N, Guerreiro Luana Tatiana Albuquerque, Martins João H, Amaral Evaldo P, Cardoso Cynthia C, Dias-Batista Ida Maria Foschiani, Silva Weber Laurentino da, Nery José Augusto C, Medeiros Priscila, Gigliotti Patricia, Campanelli Ana Paula, Virmond Marcos, Sarno Euzenir Nunes, Mira Marcelo T, Lana Francisco C F, Caffarena Ernesto Raúl, Pacheco Antonio G, Pereira Ana Carla, Moraes Milton Ozório
Abstract excerpt
Conflicting findings about the association between leprosy and TLR1 variants N248S and I602S have been reported. Here, we performed case-control and family based studies, followed by replication in 2 case-control populations from Brazil, involving 3162 individuals. Results indicated an association between TLR1 248S and leprosy in the case-control study (SS genotype odds ratio [OR], 1.81; P = .004) and the family...
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