Article
Leprosy and the adaptation of human toll-like receptor 1.
PLoS pathogens - 1 Jul 2010
Wong Sunny H, Gochhait Sailesh, Malhotra Dheeraj, Pettersson Fredrik H, Teo Yik Y, Khor Chiea C, Rautanen Anna, Chapman Stephen J, Mills Tara C, Srivastava Amit, Rudko Aleksey, Freidin Maxim B, Puzyrev Valery P, Ali Shafat, Aggarwal Shweta, Chopra Rupali, Reddy Belum S N, Garg Vijay K, Roy Suchismita, Meisner Sarah, Hazra Sunil K, Saha Bibhuti, Floyd Sian, Keating Brendan J, Kim Cecilia, Fairfax Benjamin P, Knight Julian C, Hill Philip C, Adegbola Richard A, Hakonarson Hakon, Fine Paul E M, Pitchappan Ramasamy M, Bamezai Rameshwar N K, Hill Adrian V S, Vannberg Fredrik O
Abstract excerpt
Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world. Despite several major studies on susceptibility to leprosy, few genomic loci have been replicated independently. We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent...
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