Article
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2007
Johnson Christopher M, Lyle Elizabeth A, Omueti Katherine O, Stepensky Vitaly A, Yegin Olcay, Alpsoy Erkan, Hamann Lutz, Schumann Ralf R, Tapping Richard I
Abstract excerpt
TLRs constitute an essential family of pattern recognition molecules that, through direct recognition of conserved microbial components, initiate inflammatory responses following infection. In this role, TLR1 enables host responses to a variety of bacteria, including pathogenic species of mycobacteria. In this study, we report that I602S, a common single nucleotide polymorphism within TLR1, is associated with...
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