Article
Integrated analysis of molecular and clinical prognostic factors in stage II/III colon cancer.
Journal of the National Cancer Institute - 7 Nov 2012
Roth Arnaud D, Delorenzi Mauro, Tejpar Sabine, Yan Pu, Klingbiel Dirk, Fiocca Roberto, d'Ario Giovanni, Cisar Laura, Labianca Roberto, Cunningham David, Nordlinger Bernard, Bosman Fred, Van Cutsem Eric
Abstract excerpt
BACKGROUND: The prognostic potential of individual clinical and molecular parameters in stage II/III colon cancer has been investigated, but a thorough multivariable assessment of their relative impact is missing. METHODS: Tumors from patients (N = 1404) in the PETACC3 adjuvant chemotherapy trial were examined for BRAF and KRAS mutations, microsatellite instability (MSI), chromosome 18q loss of heterozygosity...
Topics
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Biomarkers, Tumor
- Camptothecin
- Chemotherapy, Adjuvant
- Chromosomes, Human, Pair 18
- Colonic Neoplasms
- Drug Administration Schedule