Cancer-associated fibroblast signature and SMAD4 mutation in resistance to adjuvant chemotherapy in stage III colon cancer patients.

doi:10.1016/j.ejca.2026.116262

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Article

Cancer-associated fibroblast signature and SMAD4 mutation in resistance to adjuvant chemotherapy in stage III colon cancer patients.

European journal of cancer (Oxford, England : 1990) - 11 Mar 2026

Franken Ingrid A, Ketelaars Steven L C, Rubio-Alarcón Carmen, Delis-van Diemen Pien, Spaapen Tessa O M, Heilijgers Floor, da Silva Guimaraes Marcos, van Nassau Sietske C M W, Schraa Suzanna J, Mesker Wilma E, de Leng Wendy W J, Kranenburg Onno, Meijer Gerrit A, Koopman Miriam, Sausen Mark, Vink Geraldine R, Abeln Sanne, Fijneman Remond J A, Roodhart Jeanine M L

Abstract excerpt

INTRODUCTION: Stage III colon cancer (CC) is routinely treated with resection followed by adjuvant chemotherapy (ACT). However, 50 % of patients are cured by surgical intervention alone, whilst another 30 % experience disease recurrence despite ACT. This study aimed to identify biomarkers prognostic of recurrence and/or predictive of response to ACT. MATERIALS AND METHODS: Prognostic value of clinicopathological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41650786
DOI: 10.1016/j.ejca.2026.116262

Genes

SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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