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Article

Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation

31 Jul 2017

Abstract excerpt

Cytokines are protein mediators that are known to be involved in many biological processes, including cell growth, survival, inflammation, and development. To study their regulation, we generated a library of 209 different cytokines. This was used in a combinatorial format to study the effects of cytokines on each other, with particular reference to the control of differentiation. This study showed that IFN-γ is...

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PMID: 28760993
DOI: 10.1073/pnas.1706915114

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