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Article

Selective estrogen receptor modulators inhibit hepatitis C virus infection at multiple steps of the virus life cycle.

Microbes and infection - 1 Jan 2013

Murakami Yuko, Fukasawa Masayoshi, Kaneko Yukihiro, Suzuki Tetsuro, Wakita Takaji, Fukazawa Hidesuke

Abstract excerpt

We screened for hepatitis C virus (HCV) inhibitors using the JFH-1 viral culture system and found that selective estrogen receptor modulators (SERMs), such as tamoxifen, clomifene, raloxifene, and other estrogen receptor α (ERα) antagonists, inhibited HCV infection. Treatment with SERMs for the first 2 h and treatment 2-24 h after viral inoculation reduced the production of HCV RNA. Treating persistently JFH-1...

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Identifiers

PMID: 23103222
DOI: 10.1016/j.micinf.2012.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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