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Article

Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity.

Cells - 29 Jun 2021

Zapatero-Belinchón Francisco J, Ötjengerdes Rina, Sheldon Julie, Schulte Benjamin, Carriquí-Madroñal Belén, Brogden Graham, Arroyo-Fernández Laura M, Vondran Florian W R, Maasoumy Benjamin, von Hahn Thomas, Gerold Gisa

Abstract excerpt

The HCV replication cycle is tightly associated with host lipid metabolism: Lipoprotein receptors SR-B1 and LDLr promote entry of HCV, replication is associated with the formation of lipid-rich membranous organelles and infectious particle assembly highjacks the very‑low-density lipoprotein (VLDL) secretory pathway. Hence, medications that interfere with the lipid metabolism of the cell, such as statins, may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34209751
DOI: 10.3390/cells10071626
PMCID: PMC8303410

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