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Article

A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2.

Scientific reports - 21 Jun 2017

Yin Peiqi, Zhang Ling, Ye Fei, Deng Yao, Lu Sha, Li Yi-Ping, Zhang Leiliang, Tan Wenjie

Abstract excerpt

Hepatitis C virus (HCV) entry into hepatocytes is a multistep process that represents a promising target for antiviral intervention. The viral envelope protein E1E2 plays a critical role in HCV entry. In this study, we sought to identify peptide inhibitors of HCV by screening a library of overlapping peptides covering E1E2. Screening the peptide library identified several novel anti-HCV peptides. Four peptides...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28638089
DOI: 10.1038/s41598-017-04274-8
PMCID: PMC5479846

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