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Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus.

Hepatology (Baltimore, Md.) - 1 Feb 2005

Lavillette Dimitri, Tarr Alexander W, Voisset Cécile, Donot Peggy, Bartosch Birke, Bain Christine, Patel Arvind H, Dubuisson Jean, Ball Jonathan K, Cosset François-Loïc

Abstract excerpt

Because of the lack of a robust cell culture system, relatively little is known about the molecular details of the cell entry mechanism for hepatitis C virus (HCV). Recently, we described infectious HCV pseudo-particles (HCVpp) that were generated by incorporating unmodified HCV E1E2 glycoproteins into the membrane of retroviral core particles. These initial studies, performed with E1E2 glycoproteins of genotype...

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PMID: 15660396
DOI: 10.1002/hep.20542

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