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Article

Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms.

Alcohol and alcoholism (Oxford, Oxfordshire) - 10 Jul 2023

Özkan-Kotiloğlu Selin, Kaya-Akyüzlü Dilek, Yurdakul Rabia, Yıldırım Mukaddes Asena, Özgür-İlhan İnci

Abstract excerpt

AIMS: The dynorphin (DYN)/Kappa Opioid Receptor (KOR) system has been suggested to be involved in both negative affective states and the action of alcohol. The present study was undertaken to explore whether the DYN/KOR system genes, PDYN and OPRK1, influence on individual differences in the intensity of depressive symptoms at admission as well as the risk of alcohol use disorder (AUD) risk in a sample of 101...

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Identifiers

PMID: 37177778
DOI: 10.1093/alcalc/agad036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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