Article
Association of OPRK1 rs963549 and rs997917 polymorphisms with opioid use disorder and related phenotypes.
Pharmacogenomics - 1 Apr 2023
Özkan-Kotiloğlu Selin, Kaya-Akyüzlü Dilek, Yalçın-Şahiner Şafak, Ayaz Nagihan
Abstract excerpt
Aim: To evaluate the association between OPRK1 rs963549 and rs997917 and opioid use disorder (OUD) and related phenotypes. Methods: A sample of 208 individuals with (n = 100) and without (n = 108) OUD were enrolled. OPRK1 rs963549 and rs997917 were analyzed by PCR-RFLP. Craving, opioid withdrawal and the intensity of depressive and anxiety symptoms were measured by the appropriate scales. Results: OPRK1 rs963549...