Article
PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort.
PloS one - 1 Jan 2013
Preuss Ulrich W, Winham Stacey J, Biernacka Joanna M, Geske Jennifer R, Bakalkin Georgy, Koller Gabriele, Zill Peter, Soyka Michael, Karpyak Victor M
Abstract excerpt
INTRODUCTION: One of the proposed psychobiological pathways of craving attributes the desire for drinking in the context of tension, discomfort or unpleasant emotions, to "negative" (or "relief") craving. The aim of this study was to replicate a previously reported association of the PDYN rs2281285 variant with negative craving using a different phenotyping approach. METHODS: The TaqMan® Genotyping Assay was used...
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