Article
Basic concepts in RNA virus evolution.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 1996
Domingo E, Escarmís C, Sevilla N, Moya A, Elena S F, Quer J, Novella I S, Holland J J
Abstract excerpt
A hallmark of RNA genomes is the error-prone nature of their replication and retrotranscription. The major biochemical basis of the limited replication fidelity is the absence of proofreading/repair and postreplicative error correction mechanisms that normally operate during replication of cellular DNA. In spite of this unique feature of RNA replicons, the dynamics of viral populations seems to follow the same...
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