Article
Basic concepts in RNA virus evolution.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 1996
Domingo E, Escarmís C, Sevilla N, Moya A, Elena S F, Quer J, Novella I S, Holland J J
Abstract excerpt
A hallmark of RNA genomes is the error-prone nature of their replication and retrotranscription. The major biochemical basis of the limited replication fidelity is the absence of proofreading/repair and postreplicative error correction mechanisms that normally operate during replication of cellul...
Topics
- Animals
- Evolution, Molecular
- Genetic Variation
- Humans
- Mutation
- Phylogeny
- RNA Viruses