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Article

Human cytomegalovirus pUL37x1 induces the release of endoplasmic reticulum calcium stores.

Proceedings of the National Academy of Sciences of the United States of America - 12 Dec 2006

Sharon-Friling Ronit, Goodhouse Joseph, Colberg-Poley Anamaris M, Shenk Thomas

Abstract excerpt

The human CMV UL37x1-encoded protein, also known as the viral mitochondria-localized inhibitor of apoptosis, traffics to the endoplasmic reticulum and mitochondria of infected cells. It induces the fragmentation of mitochondria and blocks apoptosis. We demonstrate that UL37x1 protein mobilizes Ca(2+) from the endoplasmic reticulum into the cytosol. This release is accompanied by cell rounding, cell swelling, and...

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Identifiers

PMID: 17135350
DOI: 10.1073/pnas.0609353103
PMCID: PMC1748185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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