Article
Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase.
Proceedings of the National Academy of Sciences of the United States of America - 22 Aug 2017
He Jiuya, Carroll Joe, Ding Shujing, Fearnley Ian M, Walker John E
Abstract excerpt
The opening of a nonspecific channel, known as the permeability transition pore (PTP), in the inner membranes of mitochondria can be triggered by calcium ions, leading to swelling of the organelle, disruption of the inner membrane and ATP synthesis, and cell death. Pore opening can be inhibited by cyclosporin A mediated via cyclophilin D. It has been proposed that the pore is associated with the dimeric ATP...
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