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Article

Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 ( GAS5 )

19 Mar 2008

Abstract excerpt

The control of growth of lymphocyte populations is crucial to the physiological regulation of the immune system, and to the prevention of both leukaemic and autoimmune disease. This control is mediated through modulation of the cell cycle and regulation of cell death. During log-phase growth the rate of proliferation is high and there is a low rate of cell death. As the population density increases, the cell...

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PMID: 18354083
DOI: 10.1242/jcs.024646

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