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Article

IRF5 knockdown reverses TDP-related phenotypes partially by increasing TBK1 expression.

Brain research - 1 Jan 2023

Li Yuanyuan, Yu Lishuang, Liu Chang, Duan Weisong, Zhang Shaoran, Li Zhongyao, Yi Le, Guo Moran, Bi Yue, Li Chunyan, Liu Yakun

Abstract excerpt

Interferon-regulatory factor 5 (IRF5) participates in the regulation of apoptosis, affects the phenotype of inflammatory macrophages and plays an essential role in the inflammatory response. However, the role of IRF5 in the progression of amyotrophic lateral sclerosis (ALS) remains largely unknown. Here, we show that IRF5 mainly accumulated in the nucleus in cells expressing the truncated 25 kD C-terminal...

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Identifiers

PMID: 36343723
DOI: 10.1016/j.brainres.2022.148155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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