Article
Concordance between HIV-2 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA.
AIDS (London, England) - 14 Jan 2013
Visseaux Benoit, Charpentier Charlotte, Taieb Audrey, Damond Florence, Bénard Antoine, Larrouy Lucile, Chêne Geneviève, Brun-Vézinet Françoise, Matheron Sophie, Descamps Diane
Abstract excerpt
In this study, assessing HIV-2 tropism among 43 paired plasma/peripheral blood mononuclear cell specimens, the concordance between proviral DNA and plasma RNA genotypic tropism prediction was 74%. All the discordances were attributable to the prediction of R5 in RNA and X4/dual-mixed in DNA. HIV-2 genotypic tropism test based on proviral DNA is a suitable tool for tropism determination in HIV-2-infected patients...
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