Article
Genetic variants associated with earlier age at menopause increase the risk of cardiovascular events in women.
Menopause (New York, N.Y.) - 1 Apr 2018
Sarnowski Chloé, Kavousi Maryam, Isaacs Steve, Demerath Ellen W, Broer Linda, Muka Taulant, Franco Oscar H, Ikram Mohammad Arfan, Uitterlinden André, Franceschini Nora, Lunetta Kathryn L, Murabito Joanne M
Abstract excerpt
OBJECTIVE: To better understand the relationship between cardiovascular disease risk and age-at-natural menopause using genetic data. METHODS: Early menopause is associated with cardiovascular disease risk. We constructed a genetic risk score comprising 56 age-at-natural menopause decreasing alleles in men and women from the Framingham Heart Study, the Atherosclerosis Risk in Communities Study, and the Rotterdam...
Topics
- Adult
- Age Factors
- Cardiovascular Diseases
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Menopause, Premature
- Middle Aged
- Risk Factors