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Article

Genetic variants associated with earlier age at menopause increase the risk of cardiovascular events in women.

Menopause (New York, N.Y.) - 1 Apr 2018

Sarnowski Chloé, Kavousi Maryam, Isaacs Steve, Demerath Ellen W, Broer Linda, Muka Taulant, Franco Oscar H, Ikram Mohammad Arfan, Uitterlinden André, Franceschini Nora, Lunetta Kathryn L, Murabito Joanne M

Abstract excerpt

OBJECTIVE: To better understand the relationship between cardiovascular disease risk and age-at-natural menopause using genetic data. METHODS: Early menopause is associated with cardiovascular disease risk. We constructed a genetic risk score comprising 56 age-at-natural menopause decreasing alleles in men and women from the Framingham Heart Study, the Atherosclerosis Risk in Communities Study, and the Rotterdam...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29112599
DOI: 10.1097/GME.0000000000001017
PMCID: PMC5866156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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