Article
Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response.
Translational psychiatry - 23 Oct 2012
Ganea K, Menke A, Schmidt M V, Lucae S, Rammes G, Liebl C, Harbich D, Sterlemann V, Storch C, Uhr M, Holsboer F, Binder E B, Sillaber I, Müller M B
Abstract excerpt
Despite the overt need for improved treatment modalities in depression, efforts to develop conceptually novel antidepressants have been relatively unsuccessful so far. Here we present a translational approach combining results from hypothesis-free animal experiments with data from a genetic association study in depression. Comparing genes regulated by chronic paroxetine treatment in the mouse hippocampus with...
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