Article
[Approaches for identifying depression-related genes using animal models].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology - 1 Aug 2003
Nakatani Noriaki, Yoshikawa Takeo
Abstract excerpt
The pathophysiology of psychiatric diseases including depression is characterized by the involvement of many genes contributing a small effect. This genetic complexity means larger amounts of information can be gathered by studying the disease process as a single entity, in an animal model. A number of genetically modified animals showing both depressive and anti-depressive phenotypes have been generated....
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