Article
[Approach to depressogenic genes from genetic analyses of animal models].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica - 1 Jan 2004
Yoshikawa Takeo
Abstract excerpt
Human depression or mood disorder is defined as a complex disease, making positional cloning of susceptibility genes a formidable task. We have undertaken genetic analyses of three different animal models for depression, comparing our results with advanced database resources. We first performed quantitative trait loci (QTL) analysis on two mouse models of "despair", namely, the forced swim test (FST) and tail...
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