Article
Simultaneous detection of duplex DNA oligonucleotides using a SERS-based micro-network gradient chip.
Lab on a chip - 21 Dec 2012
Choi Namhyun, Lee Kangsun, Lim Dong Woo, Lee Eun Kyu, Chang Soo-Ik, Oh Kwang W, Choo Jaebum
Abstract excerpt
We report the development of a programmable surface-enhanced Raman scattering (SERS)-based micro-network gradient platform to simultaneously detect two different types of DNA oligomer mixtures. The utility of this platform was demonstrated by quantitative analysis of two breast cancer-related (BRCA1) DNA oligomer mixtures. To generate on-demand concentration gradients, the microfluidic circuit was designed using...
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