Article
Detection of single-base mutations using 1-D microfluidic beads array.
Electrophoresis - 1 Dec 2007
Zhang He, Yang Xiaohai, Wang Kemin, Tan Weihong, Zhou Leiji, Zuo Xinbing, Wen Jianhui, Chen Yunqing
Abstract excerpt
The application of a 1-D microfluidic beads array that is composed of individually addressable functionalized SiO2 beads has been demonstrated for detection of single-base mutations based on "sandwich" hybridization assay without additional sample labeling and PCR amplification. We concentrated on detection of mutations in the human p53 tumor suppressor gene with more than 50% mutation frequency in the known...
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