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Integrated PCR amplification and detection processes on a Lab-on-Chip platform: a new advanced solution for molecular diagnostics.

Clinical chemistry and laboratory medicine - 1 Mar 2010

Foglieni Barbara, Brisci Angela, San Biagio Floriana, Di Pietro Patrizia, Petralia Salvatore, Conoci Sabrina, Ferrari Maurizio, Cremonesi Laura

Abstract excerpt

BACKGROUND: Several microdevices have been developed to perform only a single step of a genotyping process, such as PCR or detection by probe hybridization. Here, we describe a Lab-on-Chip (LoC) platform integrating a PCR amplification microreactor with a customable microarray for the detection of sequence variations on human genomic DNA. METHODS: Preliminary work was focused on developing the single analytical...

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PMID: 20020819
DOI: 10.1515/CCLM.2010.063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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