Article
Combining Multiplex SERS Nanovectors and Multivariate Analysis for In Situ Profiling of Circulating Tumor Cell Phenotype Using a Microfluidic Chip.
Small (Weinheim an der Bergstrasse, Germany) - 1 May 2018
Zhang Yizhi, Wang Zhuyuan, Wu Lei, Zong Shenfei, Yun Binfeng, Cui Yiping
Abstract excerpt
Isolating and in situ profiling the heterogeneous molecular phenotype of circulating tumor cells are of great significance for clinical cancer diagnosis and personalized therapy. Herein, an on-chip strategy is proposed that combines size-based microfluidic cell isolation with multiple spectrally orthogonal surface-enhanced Raman spectroscopy (SERS) analysis for in situ profiling of cell membrane proteins and...
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