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Article

A microfluidic chip for rapid analysis of DNA melting curves for BRCA2 mutation screening.

Lab on a chip - 21 Oct 2020

Lin Xuyan, Nagl Stefan

Abstract excerpt

A microfluidic chip integrated with a microheater and a luminescent temperature sensor for rapid, spatial melting curve analysis was developed and applied for the screening of a breast cancer gene fragment. The method could detect genetic differences in around 3 minutes total for the whole procedure, which is much faster than established procedures. A microfabrication technique was developed to allow for bonding...

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PMID: 32926049
DOI: 10.1039/d0lc00624f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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