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Article

A single nucleotide polymorphism in IL28B affects viral evolution of hepatitis C quasispecies after pegylated interferon and ribavirin therapy.

Journal of medical virology - 1 Dec 2012

Yuan Hejun, Adams-Huet Beverley, Petersen Tianna, Attar Nahid, Lee William M, Jain Mamta K

Abstract excerpt

Interleukin-28B (IL28B) polymorphisms are associated with viral response to peginterferon and ribavirin (RBV) in chronic hepatitis C (HCV). Their recognition represents a breakthrough in the understanding of the role of the host in viral eradication. How these polymorphisms determine viral eradication is unknown. The IL-28B variants are hypothesized to have a differential impact on HCV quasispecies evolution...

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Source

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Identifiers

PMID: 23080496
DOI: 10.1002/jmv.23407
PMCID: PMC3481197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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