Interleukin 28B gene variation at rs12979860 determines early viral kinetics during treatment in patients carrying genotypes 2 or 3 of hepatitis C virus.

doi:10.1093/infdis/jir193

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Article

Interleukin 28B gene variation at rs12979860 determines early viral kinetics during treatment in patients carrying genotypes 2 or 3 of hepatitis C virus.

The Journal of infectious diseases - 15 Jun 2011

Lindh Magnus, Lagging Martin, Färkkilä Martti, Langeland Nina, Mørch Kristine, Nilsson Staffan, Norkrans Gunnar, Pedersen Court, Buhl Mads Rauning, Westin Johan, Hellstrand Kristoffer

Abstract excerpt

Single-nucleotide polymorphisms upstream of the interleukin 28B (interferon λ3) gene (IL28B) strongly influence treatment efficacy in patients carrying hepatitis C virus (HCV) of genotype 1. In patients receiving 12 or 24 weeks of interferon-ribavirin therapy for infection with genotype 2 or 3 (n = 341), we found that rs12979860 strikingly determined the first phase of viral elimination (P < .001). In patients...

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PMID: 21606533
DOI: 10.1093/infdis/jir193

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