Article
Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients.
AIDS (London, England) - 15 May 2010
Rallón Norma I, Naggie Susanna, Benito José M, Medrano José, Restrepo Clara, Goldstein David, Shianna Kevin V, Vispo Eugenia, Thompson Alex, McHutchison John, Soriano Vincent
Abstract excerpt
BACKGROUND: Given that peginterferon-ribavirin treatment is poorly tolerated, there is interest in the identification of predictors of response, particularly in HIV/hepatitis C virus (HCV)-coinfected patients that respond less than HCV-monoinfected individuals. A single nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) has been shown to predict treatment response in HCV-monoinfected patients carrying...
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