Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C.

doi:10.1093/infdis/jiq098

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Article

Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C.

The Journal of infectious diseases - 1 Mar 2011

Nattermann Jacob, Vogel Martin, Nischalke Hans Dieter, Danta Mark, Mauss Stefan, Stellbrink Hans-Jörg, Baumgarten Axel, Mayr Christoph, Bruno Raffaele, Tural Cristina, Klausen Gerd, Clotet Bonaventura, Naumann Uwe, Lutz Thomas, Rausch Michael, Schewe Knud, Bienek Bernhard, Haerter Georg, Sauerbruch Tilman, Rockstroh Juergen K, Spengler Ulrich

Abstract excerpt

Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In...

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PMID: 21257738
DOI: 10.1093/infdis/jiq098
PMCID: PMC3072731

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