Article
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
Cancer research - 15 Nov 2007
Martin Eric S, Tonon Giovanni, Sinha Raktim, Xiao Yonghong, Feng Bin, Kimmelman Alec C, Protopopov Alexei, Ivanova Elena, Brennan Cameron, Montgomery Kate, Kucherlapati Raju, Bailey Gerald, Redston Mark, Chin Lynda, DePinho Ronald A
Abstract excerpt
Colorectal cancer (CRC) is a major cause of cancer morbidity and mortality, and elucidation of its underlying genetics has advanced diagnostic screening, early detection, and treatment. Because CRC genomes are characterized by numerous non-random chromosomal structural alterations, we sought to delimit regions of recurrent amplifications and deletions in a collection of 42 primary specimens and 37 tumor cell...
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