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Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer

18 Aug 2009

Abstract excerpt

To evaluate the mechanisms and consequences of chromosomal aberrations in colorectal cancer (CRC), we used a combination of spectral karyotyping, array comparative genomic hybridization (aCGH), and array-based global gene expression profiling on 31 primary carcinomas and 15 established cell lines. Importantly, aCGH showed that the genomic profiles of primary tumors are recapitulated in the cell lines. We revealed...

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PMID: 19691111
DOI: 10.1002/gcc.20699

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