Article
Lamin A/C mutation is independently associated with an increased risk of arterial and venous thromboembolic complications.
International journal of cardiology - 20 Sept 2013
van Rijsingen Ingrid A W, Bakker Annemieke, Azim Donija, Hermans-van Ast Johanna F, van der Kooi Anneke J, van Tintelen J Peter, van den Berg Maarten P, Christiaans Imke, Lekanne Dit Deprez Ronald H, Wilde Arthur A M, Zwinderman Aeilko H, Meijers Joost C M, Grootemaat Anita E, Nieuwland Rienk, Pinto Yigal M, Pinto-Sietsma Sara-Joan
Abstract excerpt
BACKGROUND: Lamin A/C (LMNA) mutation carriers suffer from a variety of clinical phenotypes, including dilated cardiomyopathy (DCM). Although it has been suggested that carriers are at risk for thromboembolic complications, it is unknown whether this risk is higher than can be expected from the underlying cardiac abnormalities. The purpose of this study was to determine whether a LMNA mutation is associated with...
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