Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers.

doi:10.1161/CIRCGENETICS.116.001603

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Article

Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers.

Circulation. Cardiovascular genetics - 1 Dec 2017

Nishiuchi Suguru, Makiyama Takeru, Aiba Takeshi, Nakajima Kenzaburo, Hirose Sayako, Kohjitani Hirohiko, Yamamoto Yuta, Harita Takeshi, Hayano Mamoru, Wuriyanghai Yimin, Chen Jiarong, Sasaki Kenichi, Yagihara Nobue, Ishikawa Taisuke, Onoue Kenji, Murakoshi Nobuyuki, Watanabe Ichiro, Ohkubo Kimie, Watanabe Hiroshi, Ohno Seiko, Doi Takahiro, Shizuta Satoshi, Minamino Tohru, Saito Yoshihiko, Oginosawa Yasushi, Nogami Akihiko, Aonuma Kazutaka, Kusano Kengo, Makita Naomasa, Shimizu Wataru, Horie Minoru, Kimura Takeshi

Abstract excerpt

BACKGROUND: Mutations in LMNA (lamin A/C), which encodes lamin A and C, typically cause age-dependent cardiac phenotypes, including dilated cardiomyopathy, cardiac conduction disturbance, atrial fibrillation, and malignant ventricular arrhythmias. Although the type of LMNA mutations have been reported to be associated with susceptibility to malignant ventricular arrhythmias, the gene-based risk stratification for...

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PMID: 29237675
DOI: 10.1161/CIRCGENETICS.116.001603

Genes

LMNA

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