Article
High yield of LMNA mutations in patients with dilated cardiomyopathy and/or conduction disease referred to cardiogenetics outpatient clinics.
American heart journal - 1 Dec 2007
van Tintelen J Peter, Hofstra Robert M W, Katerberg Hilga, Rossenbacker Tom, Wiesfeld Ans C P, du Marchie Sarvaas Gideon J, Wilde Arthur A M, van Langen Irene M, Nannenberg Eline A, van der Kooi Anneke J, Kraak Marian, van Gelder Isabelle C, van Veldhuisen Dirk Jan, Vos Yvonne, van den Berg Maarten P
Abstract excerpt
BACKGROUND: Among the most frequently encountered mutations in dilated cardiomyopathy (DCM) are those in the lamin A/C (LMNA) gene. Our goal was to analyze the LMNA gene in patients with DCM and/or conduction disease referred to the cardiogenetics outpatient clinic and to evaluate the prevalence of LMNA mutations and their clinical expression. METHODS AND RESULTS: The LMNA gene was screened in 61 index patients....
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