Article
Risk factors for malignant ventricular arrhythmias in lamin a/c mutation carriers a European cohort study.
Journal of the American College of Cardiology - 31 Jan 2012
van Rijsingen Ingrid A W, Arbustini Eloisa, Elliott Perry M, Mogensen Jens, Hermans-van Ast Johanna F, van der Kooi Anneke J, van Tintelen J Peter, van den Berg Maarten P, Pilotto Andrea, Pasotti Michele, Jenkins Sharon, Rowland Camilla, Aslam Uzma, Wilde Arthur A M, Perrot Andreas, Pankuweit Sabine, Zwinderman Aeilko H, Charron Philippe, Pinto Yigal M
Abstract excerpt
OBJECTIVES: The purpose of this study was to determine risk factors that predict malignant ventricular arrhythmias (MVA) in Lamin A/C (LMNA) mutation carriers. BACKGROUND: LMNA mutations cause a variety of clinical phenotypes, including dilated cardiomyopathy and conduction disease. Many LMNA mutation carriers have a poor prognosis, because of a high frequency of MVA and progression to end-stage heart failure....
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